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CEA OR Collie Eye Anomaly
 
About 95% of collies have some form of CEA. This eye exam can only be given by a Certified Canine Ophthalmologist NOT A VET. CEA or Collie Eye Anomaly is thought to be inherited by an autosomal recessive gene.
 
A recessive trait means there are three types of dogs: unaffected dogs that do not display the trait NOR have genes for the trait; carriers that do not display the trait, but DO have one of the genes for the trait; and affected dogs that have the trait and can only pass along genes for the trait. If a dog is "mildly affected", it is an affected dog and will always pass along CEA to it's puppies. So breeding two "mildly affected" dogs will never result in unaffected, or even carrier puppies. Breeding two apparently normal dogs may result in puppies with CEA if both dogs turn out to be carriers. If a dog ever produces a puppy with CEA, then that dog must be either a carrier or an affected dog itself.
 
REPUTABLE breeders will ALWAYS have eye exams done on their puppies, even if the parents are normal eyed. This is because the Collie Eye Anomaly gene is recessive and two normal eyed dogs CAN still throw an affected dog. Make sure that any puppy that you buy comes with a Certified Eye Check and that you receive those papers. Buying a puppy without an eye check is extremely risky.
 
An affected dog is one who, upon dilation of the eye, shows a visible deviation from a normal or unaffected eye when viewed with the proper instruments. To be affected a dog would have inherited an affected gene from both parents. Unless the condition is a DETACHED RETINA, a collie with CEA CAN live a normal healthy life.
 

Normal: A “Normal” eye rating is of course the best grading there is. (There are also "Go Normals", which are so mildly affected at a young age, that later, the pale areas disappear, leading to what is termed a "Go Normal". Keep in mind that these are still in fact affected with CEA). There are variations even in "Normal" eyes. These correspond somewhat to a dog's coat color. Thus it is often difficult to judge the pigment in a Blue Merle's eyes as it is diluted along with his coat color.

Choroidal Hypoplasia, Chorioretinal Change:These refer to abnormalities in the coloring or pigmentation of the choroid or central layer of the eye's lining. This is the most common abnormality found in Collie eyes. Often referred to as mild CRC, Grade I or Grade II, it is the least harmful and least severe form of CEA. Most dogs with this eye grade function normally with no ill-effects or loss of vision.

Staphyloma, Coloboma, Ectasia: While not completely synonymous, these terms all refer to a cupping or bulging in the eyeball usually in the area of the optic disc.

Vascular Disease, Tortuous Blood Vessels:Defects in the vessels of the eye which are responsible for its blood supply or "nourishment." These may be malformed, undersized, or even lacking.

Retinal Detachment: Loosening or separation of the inmost, or retina, layer from the wall of the eye. This may involve a tiny area or the entire retina. It can be either one or both eyes. The complete detachment of the retina results in blindness in that eye.

Merle Collies

The fundus of the Merle Collies present a special challenge in differentiating affected individuals from non-affected in terms of Collie eye anomaly. The Merle fundus is often lightly pigmented and exhibits a normal amount of choroid hypoplasia. Some of these individuals cannot be designated as normal based on a clinical examination. Test breeding may be required.

There is a new Genetic Test for Collie Eye Anomaly / Choroidal Hypoplasia. Please visit the OPTIGEN website for details

The OptiGen genetic test for CEA/CH provides a powerful management tool for the breeder. This genetic test can distinguish all three genetic states – normal, carrier and affected. With this information, the breeder can plan matings that avoid producing any affected dogs by always selecting one parent that is normal. The other parent can be normal, carrier or even affected, and no affected dogs will result. (See table at the end.) This breeding recommendation is a big step forward, especially for breeds and countries where frequency of CEA/CH is much lower. Earlier advice cautioned against breeding affected dogs, their parents, their offspring or their siblings (unless eye exams before 3 months of age demonstrate the sib is unaffected).

Understandably, genetic testing will be a difficult tool to use for some breeders of “standard” collies (i.e., Rough, Smooth, Show, Standard) where the disease is very common. In some circumstances, genetically normal – homozygous normal – collies could be difficult to find and it may not be practical for the breeder to plan matings that include one normal dog. And, it may not be reasonable to expect complete avoidance of CEA/CH in one generation. All the same, genetic testing is a sure-fire tool to move toward elimination of the disease. To start, breeding a carrier to a carrier will produce an average of 25% normals, 50% carriers and 25% affecteds. With genetic testing at each subsequent generation, and with a goal of breeding normal by carrier or normal by affected, the frequency of disease will drop and frequency of normals will increase without loss of other desirable traits valued in collies.

A normal eyed dog is a dog who, when examined by a veterinary ophthalmologist shows no visible signs of CEA, but possesses only one normal gene; the other gene is affected.
 
A non-carrier is a normal eyed collie who carries no affected genes. He cannot produce anything but normal eyed collies
 
If you are buying a pup with a normal eye check and the breeder tells you that BOTH parents are affected, don't believe it. It's not possible to get normal eyes from two affected parents. Either the eye check was wrong, or the sire of record is false. CEA is a recessive gene, taking two affected genes to make an affected eye. One affected gene makes a normal eye, but a carrier. Since there are only two genes involved (one from each parent), and both parents are affected (two affected genes each), the pup must be affected.
 
A non-carrier cannot be diagnosed by an eye check, as we are dealing with genes not effects of genes. If a dog comes from two non-carrier parents, he is a non-carrier. Whether or not a dog is a non-carrier can only be defined by breeding. If a dog produces a significant number of puppies, bred to an affected or normal eyed stud or bitch, and all have normal eyes, no matter what the eye check of the other parent is, it's a safe bet he/she is a non-carrier. However Optigen testing is the only way to be absolutely sure.

Progressive Retinal Atrophy

PRA will result in blindness. A well known and widely used stud dog in the '70s was found to be a carrier and did produce blind puppies. While the breeder now test-breeds all their stock available for stud services, PRA is present in a number of lines. Most reputable breeders who know or suspect that PRA is in their lines do test-breed. Since PRA in Collies is a simple recessive, it has been easier to control than CEA.

ALL reputable breeders should eye check not
only their breeding stock, but all
puppies that are offered for sale.

Possible genes (one gene from each parent for a total of 2 genes per dog)
a - affected gene (recessive gene)
N - Normal-eyed gene (dominant gene)

Possible combinations (per dog)
NN-----> Normal eyed non-carrier
Na ------> Normal eyed carrier
aa -------> affected dog

 

The sire is affected.
The dam is affected.
Offspring:
All affected.

 

The sire is a normal-eyed carrier.
The dam is affected.
Offspring:
1/2 are normal-eyed carriers.
1/2 are affected.

 

The sire is a normal-eyed non-carrier.
The dam is affected.
Offspring:
All normal-eyed carriers

 

The sire is a normal-eyed non-carrier.
The dam is normal-eyed carrier.

Offspring:
1/2 normal-eyed carriers.
1/2 normal-eyed non-carriers

 

The sire is a normal-eyed carrier.
The dam is normal-eyed carrier.
Offspring:
1/2 normal-eyed carriers.
1/4 normal-eyed non-carriers.

1/4 are affected.

 

The sire is a normal-eyed non-carrier.
The dam is normal-eyed non-carrier.
Offspring:
All normal-eyed non-carriers

In Layman's terms the above chart simply means:

Affected to Affected: This breeding would produce ALL affected pups. Both parents have only affected genes and can therefore only pass on affected genes.


Affected to Normal Eyed: This breeding should produce 50% normal eyed carriers and 50% affected. Only one gene is required to be normal eyed, the normal eyed parent should produce the normal eyed gene 50% of the time.

Affected to Non-Carrier: This breeding will produce All Normal eyed carriers.


Normal Eyed to Normal Eyed: This breeding should produce normal eyed non-carriers, normal eyed carriers and affected dogs. It is interesting to note that breeders have found that the percentage of affected dogs, which should be equal to that of non-carriers, out weighs that of non-carriers and of normal eyed dogs. Very few non-carriers have ever come from normal to normal breeding's. Normal eyed dogs which have a non-carrier in their immediate background appear to produce a greater percentage of non-carriers.


Non-Carrier to Normal Eyed: Should produce 50% normal eyes and 50% normal eyed non-carriers. Again it only requires one affected gene to be a carrier, and the normal eyed parent should produce the normal eyed gene 50% of the time. Unfortunately there has not been enough non-carrier to normal eyed breeding's to establish whether or not this is how it is actually working.


Non-Carrier to Non-Carrier: This breeding can only produce non-carriers. A dog cannot pass on a gene it doesn't have. Much confusion has historically been present, and is still present in the collie world, due to the lack of uniformity in grading systems. The advent of the CERF form with its diagnostic terms rather than a numerical grading system, is helping to clear up some of the problems with credibility of eye checks.

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